Chen, L., Hong, M., Luan, C., et al. D.Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models. Nature biotechnology (2025).
Chen, L., Luan, C., Hong, M., et al. D.A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes. Nature biotechnology (2025).
Wang, D., Wang, X., Tan, B., et al. Allogeneic CD19-targeted CAR-T therapy in refractory systemic lupus erythematosus achieved durable remission. Med (2025).
Yang, C., Sun, C., Tan, B., Hu, C., Wan, L., Wang, C., Shi, X., Qin, J., Zhang, N., Zheng, B., Liu, M., Lin, J., Du, B., & Tong, H. Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus. Cell research(2025).
Tan, B., Tu, C., Xiong, H., Xu, Y., Shi, X., Zhang, X., Yang, R., Zhang, N., Lin, B., Liu, M., Qin, J., & Du, B. GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy. Molecular therapy (2025).
Xue N., Hong D., Zhang D., et al. Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos. Molecular Cell (2024).
Wang X., Wu X., Tan B., et al. Allogeneic CD19-targeted CAR-T therapy in severe myositis and systemic sclerosis achieved durable remission and reversed extensive fibrotic damages. Cell (2024).
Yang L., Huo Y., Wang M., et al. Engineering APOBEC3A deaminase for highly accurate and efficient base editing. Nature Chemical Biology (2024).
Zhang, N., Liu, X., Qin, J., et al. LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment. Molecular Therapy (2023).
Chen, L., Hong, M., Luan, C., et al. Adenine transversion editors enable precise, efficient A·T-to-C•G base editing in mammalian cells and embryos. Nature Biotechnology (2023).
Chen, L., Zhu, B., Ru, G., et al. Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing. Nature Biotechnology (2022).
Chen, L., Zhang, S., Xue, N., et al. Engineering a precise adenine base editor with minimal bystander editing. Nature Chemical Biology (2022).
